DNA Repair Has a New FAN1 Club

被引：11
|
作者：
O'Donnell, Lara [1 ]
Durocher, Daniel [1 ,2 ]
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada
来源：
MOLECULAR CELL | 2010年 / 39卷 / 02期
关键词：
CROSS-LINK REPAIR; MONOUBIQUITINATED FANCD2; NUCLEASE; IDENTIFICATION; KIAA1018/FAN1; PATHWAY;
D O I：
10.1016/j.molcel.2010.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In recent issues of Molecular Cell, Cell, and Science, Smogorzewska et al. (2010), MacKay et al. (2010), Kratz et al. (2010), and Liu et al. (2010) identify FAN1 as a nuclease that is recruited to sites of interstrand crosslinks by ubiquitylated FANCD2, where it participates in DNA repair. The identification of FAN1 fills a missing link in interstrand crosslink DNA repair.
引用
收藏
页码：167 / 169
页数：3
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