Time-dependent changes in excitability after one-trial conditioning of Hermissenda

被引:17
|
作者
Crow, T [1 ]
Siddiqi, V [1 ]
机构
[1] Univ Texas, Sch Med, Dept Neurobiol & Anat, Houston, TX 77225 USA
关键词
D O I
10.1152/jn.1997.78.6.3460
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The visual system of Hermissenda has been studied extensively as a site of cellular plasticity produced by classical conditioning. A one-trial conditioning procedure consisting of light paired with the application of serotonin (5-HT) to the exposed, but otherwise intact, nervous system produces suppression of phototactic behavior tested 24 h after conditioning. Short-and long-term enhancement (STE and LTE) of excitability in identified type B photoreceptors is a cellular correlate of one-trial conditioning. LTE can be expressed in the absence of STE suggesting that STE and LTE may be parallel processes. To examine the development of enhancement, we studied its time-dependent alterations after one-trial conditioning. Intracellular recordings from identified type B photoreceptors of independent groups collected at different times after conditioning revealed that enhanced excitability follows a biphasic pattern in its development. The analysis of spikes elicited by 2 and 30 s extrinsic current pulses at different levels of depolarization showed that enhancement reached a peak 3 h after conditioning. From its peak, excitability decreased toward baseline control levels 5-6 h after conditioning followed by an increase to a stable plateau at 16 to 24 h postconditioning. Excitability changes measured in cells from unpaired control groups showed maximal changes 1 h posttreatment that rapidly decremented within 2 h. The conditioned stimulus (CS) elicited significantly more spikes 24 h postconditioning for the conditioned group as compared with the unpaired control group. The analysis of the time-dependent development of enhancement may reveal the processes underlying different stages of memory for this associative experience.
引用
收藏
页码:3460 / 3464
页数:5
相关论文
共 50 条
  • [1] Time-dependent increase in protein phosphorylation following one-trial enhancement in Hermissenda
    Crow, T
    Siddiqi, V
    Zhu, Q
    Neary, JT
    JOURNAL OF NEUROCHEMISTRY, 1996, 66 (04) : 1736 - 1741
  • [2] An inhibitor of the map kinase cascade inhibits protein phosphorylation detected after one-trial conditioning of Hermissenda.
    XueBian, JJ
    Siddiqi, V
    Crow, T
    FASEB JOURNAL, 1997, 11 (03): : 3657 - 3657
  • [3] One-trial in vitro conditioning of Hermissenda regulates phosphorylation of Ser-122 of Csp24
    Crow, Terry
    Xue-Bian, Juan-Juan
    THYMOSINS IN HEALTH AND DISEASE: FIRST INTERNATIONAL SYMPOSIUM, 2007, 1112 : 189 - 200
  • [4] Time-dependent changes in cortical excitability after prolonged visual deprivation
    Pitskel, Naomi B.
    Merabet, Lotfi B.
    Ramos-Estebanez, Ciro
    Kauffman, Thomas
    Pascual-Leone, Alvaro
    NEUROREPORT, 2007, 18 (16) : 1703 - 1707
  • [5] FACTORS GOVERNING ONE-TRIAL CONTEXTUAL CONDITIONING
    FANSELOW, MS
    ANIMAL LEARNING & BEHAVIOR, 1990, 18 (03): : 264 - 270
  • [6] ONE-TRIAL INSTRUMENTAL-CONDITIONING IN RATS
    SCHULZ, H
    ACTA PHYSIOLOGICA HUNGARICA, 1987, 70 (01) : 111 - 115
  • [7] Critical time-window for NO-cGMP-dependent long-term memory formation after one-trial appetitive conditioning
    Kemenes, I
    Kemenes, G
    Andrew, RJ
    Benjamin, PR
    O'Shea, M
    JOURNAL OF NEUROSCIENCE, 2002, 22 (04): : 1414 - 1425
  • [8] One-trial in vitro conditioning regulates a cytoskeletal-related protein (CSP24) in the conditioned stimulus pathway of Hermissenda
    Crow, T
    Xue-Bian, JJ
    JOURNAL OF NEUROSCIENCE, 2002, 22 (24): : 10514 - 10518
  • [9] A single time-window for protein synthesis-dependent long-term memory formation after one-trial appetitive conditioning
    Fulton, D
    Kemenes, I
    Andrew, RJ
    Benjamin, PR
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (05) : 1347 - 1358
  • [10] One-trial appetitive conditioning in the sexual behavior system
    Hilliard, S
    Nguyen, M
    Domjan, M
    PSYCHONOMIC BULLETIN & REVIEW, 1997, 4 (02) : 237 - 241