Synthesis and antituberculosis activity of 2-(aryl/alkylamino)-5-(4-aminophenyl)-1,3,4-thiadiazoles and their Schiff bases

被引：58
|
作者：
Solak, Nilufer [1 ]
Rollas, Sevim [1 ]
机构：
[1] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey
来源：
ARKIVOC | 2006年
关键词：
Schiff bases; 1,3,4-thiadiazoles; antituberculosis activity; synthesis;
D O I：
10.3998/ark.5550190.0007.c20
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new Schiff bases were synthesized through the condensation reaction of 1,3,4-thiadiazoles containing a aromatic primary amine and 3-hydroxybenzaldehyde, salicylaldehyde, 5-nitrofurfuraldehyde or 3-nitrobenzaldehyde. The synthesized compounds screened for antituberculosis activity against Mycobacterium tuberculosis H(37)Rv using BACTEC 460 radiometric system. Among the tested compounds, 2-phenylamino-5-[4-(2-hydroxybenzylideneamino)phenyl]-1,3,4-thiadiazol (5a) showed the highest inhibitory activity (51%). The activities of the synthesized Schiff bases were compared with those of the starting 2-(aryl/alkylamino)-5-(4-aminophenyl)-1,3,4-thiadiazoles (4a-e). Some Schiff bases showed higher growth inhibition than the starting amines.
引用
收藏
页码：173 / 181
页数：9
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