Novel synthesis of condensed pyridin-2(1H)-one and pyrimidine derivatives

The reaction of N-chloroacetyl derivatives 6-10 with morpholine yielded N-morpholin-1-yl acetyl derivatives 11-15, which were subjected to Thorpe-Zieler cyclization with sodium tent-butoxide to produce the corresponding condensed pyridin-2(1H)-one derivatives 16-20. Treatment of compounds 1, 6-10 with either malononitrile or pchlorobenzylidinemalononitrile in presence of triethylamine, afforded the corresponding pyrimidines 21-25, 27 and pyridine derivative 26 respectively. Moreover compound la teas treated with ethyl isothiocyanoacetate to give the corresponding piprazine derivative 28.