Protection of trivalent inactivated influenza vaccine against hospitalizations among pandemic influenza A (H1N1) cases in Argentina

被引:24
|
作者
Orellano, P. W. [1 ]
Reynoso, J. I. [1 ]
Carlino, O. [1 ]
Uez, O. [1 ]
机构
[1] Minist Salud Tierra Fuego, Dept Epidemiol, RA-9410 Ushuaia, Tierra Fuego, Argentina
关键词
Influenza A virus; H1N1; subtype; Influenza vaccine; Argentina; FIELD;
D O I
10.1016/j.vaccine.2010.05.051
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The aim of this study was to estimate the effectiveness of 2009 seasonal trivalent inactivated vaccine in reducing hospitalizations due to the novel influenza A H1N1 virus among positive cases. Data collected from Argentina's national epidemiological surveillance system were analyzed. All patients had a clinical diagnosis and underwent positive serological tests for pandemic influenza A H1N1. Logistic regression was used to estimate vaccine effectiveness to prevent severe cases of the disease, measured as hospitalizations. The adjusted effectiveness of the vaccine was 50% (95% CI: 40-59%). Vaccination was significantly associated with hospitalizations in all age groups, and within groups that had and had not received antiviral treatment. These results suggest that seasonal influenza vaccine might have conferred partial protection against severe cases due to the novel pandemic influenza. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5288 / 5291
页数:4
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