Ligusaginoids A-D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta

被引：9
|
作者：
Li, Hang-Ying [1 ]
Zheng, Zai-Qin [1 ]
Wei, Wen-Jun [1 ]
Chen, Jian-Jun [1 ]
Gao, Kun [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 38期
基金：
中国国家自然科学基金;
关键词：
Ligularia sagitta; Eremophilane; Sesquiterpenoid; Structure determination; Antibacterial activities; CONSTITUENTS;
D O I：
10.1016/j.tetlet.2018.08.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four novel highly oxygenated eremophilane-type sesquiterpenoid dimers and trimers with the unique 6/6/5/5 polycyclic skeleton, designated as ligusaginoids A-D (1-4), were isolated from the aerial parts of Ligularia sagitta. Their structures with absolute configurations were determined by a combined method. Moreover, a plausible biosynthetic pathway of 1-4 was also proposed. These compounds showed weak antibacterial activities. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3461 / 3466
页数：6
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