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Clinical, neuroimaging and neurophysiological features in addicts with manganese-ephedrone exposure
被引:37
|作者:
Sikk, K.
[1
]
Taba, P.
[1
]
Haldre, S.
[1
]
Bergquist, J.
[2
]
Nyholm, D.
[3
]
Askmark, H.
[3
]
Danfors, T.
[3
,4
]
Sorensen, J.
[4
]
Thurfjell, L.
[5
]
Raininko, R.
[6
]
Eriksson, R.
[6
]
Flink, R.
[3
]
Farnstrand, C.
[3
]
Aquilonius, S. -M.
[3
]
机构:
[1] Univ Tartu, Dept Neurol & Neurosurg, EE-51014 Tartu, Estonia
[2] Uppsala Univ, Dept Phys & Analyt Chem, Uppsala, Sweden
[3] Uppsala Univ, Dept Neurosci, Uppsala, Sweden
[4] Univ Uppsala Hosp, Dept Nucl Med, Uppsala, Sweden
[5] Uppsala Univ, GE Healthcare Med Diagnost Res & Dev, Uppsala, Sweden
[6] Uppsala Univ, Dept Radiol, Uppsala, Sweden
来源:
ACTA NEUROLOGICA SCANDINAVICA
|
2010年
/
121卷
/
04期
基金:
瑞典研究理事会;
关键词:
drug addiction;
ephedrone;
manganism;
methcathinone;
neuroimaging;
neurophysiology;
parkinsonism;
POSITRON-EMISSION-TOMOGRAPHY;
METHAMPHETAMINE ABUSERS;
PROTRACTED ABSTINENCE;
INDUCED PARKINSONISM;
METHCATHINONE USERS;
NONHUMAN-PRIMATES;
FOLLOW-UP;
BRAIN;
INTOXICATION;
ENCEPHALOPATHY;
D O I:
10.1111/j.1600-0404.2009.01189.x
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Objective - To identify biomarkers supporting the clinical diagnosis of manganism in patients several years after exposure to manganese (Mn). Methods - Neurophysiological examinations, magnetic resonance imaging (MRI), single-photon emission computed tomography and fluorodeoxyglycose (FDG) positron emission tomography were performed in four former ephedrone addicts with extrapyramidal symptoms. Results - Peripheral nervous system was not affected. No patients had reduced uptake of 123I Ioflupane in the striatum. MRI signal intensities were slightly changed in the basal ganglia. All patients showed a widespread, but not uniform, pathological pattern of FDG uptake with changes mainly located to the central part of the brain including the basal ganglia and the surrounding white matter. Conclusions - Presynaptic neurons in the nigrostriatal pathway are intact in Mn-induced parkinsonism after prolonged abstinence from ephedrone. The diagnosis is principally based on clinical signs and the history of drug abuse.
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页码:237 / 243
页数:7
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