Clinical, neuroimaging and neurophysiological features in addicts with manganese-ephedrone exposure

被引:37
|
作者
Sikk, K. [1 ]
Taba, P. [1 ]
Haldre, S. [1 ]
Bergquist, J. [2 ]
Nyholm, D. [3 ]
Askmark, H. [3 ]
Danfors, T. [3 ,4 ]
Sorensen, J. [4 ]
Thurfjell, L. [5 ]
Raininko, R. [6 ]
Eriksson, R. [6 ]
Flink, R. [3 ]
Farnstrand, C. [3 ]
Aquilonius, S. -M. [3 ]
机构
[1] Univ Tartu, Dept Neurol & Neurosurg, EE-51014 Tartu, Estonia
[2] Uppsala Univ, Dept Phys & Analyt Chem, Uppsala, Sweden
[3] Uppsala Univ, Dept Neurosci, Uppsala, Sweden
[4] Univ Uppsala Hosp, Dept Nucl Med, Uppsala, Sweden
[5] Uppsala Univ, GE Healthcare Med Diagnost Res & Dev, Uppsala, Sweden
[6] Uppsala Univ, Dept Radiol, Uppsala, Sweden
来源
ACTA NEUROLOGICA SCANDINAVICA | 2010年 / 121卷 / 04期
基金
瑞典研究理事会;
关键词
drug addiction; ephedrone; manganism; methcathinone; neuroimaging; neurophysiology; parkinsonism; POSITRON-EMISSION-TOMOGRAPHY; METHAMPHETAMINE ABUSERS; PROTRACTED ABSTINENCE; INDUCED PARKINSONISM; METHCATHINONE USERS; NONHUMAN-PRIMATES; FOLLOW-UP; BRAIN; INTOXICATION; ENCEPHALOPATHY;
D O I
10.1111/j.1600-0404.2009.01189.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective - To identify biomarkers supporting the clinical diagnosis of manganism in patients several years after exposure to manganese (Mn). Methods - Neurophysiological examinations, magnetic resonance imaging (MRI), single-photon emission computed tomography and fluorodeoxyglycose (FDG) positron emission tomography were performed in four former ephedrone addicts with extrapyramidal symptoms. Results - Peripheral nervous system was not affected. No patients had reduced uptake of 123I Ioflupane in the striatum. MRI signal intensities were slightly changed in the basal ganglia. All patients showed a widespread, but not uniform, pathological pattern of FDG uptake with changes mainly located to the central part of the brain including the basal ganglia and the surrounding white matter. Conclusions - Presynaptic neurons in the nigrostriatal pathway are intact in Mn-induced parkinsonism after prolonged abstinence from ephedrone. The diagnosis is principally based on clinical signs and the history of drug abuse.
引用
收藏
页码:237 / 243
页数:7
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