Urinary levels of monocyte chemoattractant protein (MCP)-1 and disease activity in patients with IgA nephropathy

被引：0
|
作者：
Saitoh, A
Suzuki, Y
Takeda, M
Kubota, K
Itoh, K
Tomino, Y
机构：
[1] Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Tokyo 113, Japan
[2] Special Reference Lab, Tokyo, Japan
[3] Kanagawa Prefectural Coll Nursing & Med Technol, Kanagawa, Japan
来源：
JOURNAL OF CLINICAL LABORATORY ANALYSIS | 1998年 / 12卷 / 01期
关键词：
MCP-1; ELISA; urine; renal histology; IgA nephropathy;
D O I：
10.1002/(SICI)1098-2825(1998)12:1<1::AID-JCLA1>3.0.CO;2-F
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Using a quantitative sandwich ELISA, we studied 17 patients with IgA nephropathy to determine if levels of urinary monocyte chemoattractant protein-1 (MCP-1) might reflect the disease activity. The levels of urinary MCP-1 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease, or in healthy controls. The results showed a significant correlation between the levels of urinary MCP-1 and the disease activity, i.e., levels of urinary casts and urinary protein. It was thus suggested that the measurement of urinary MCP-1 is useful in evaluating the degree of renal invanced juries and/or prognosis in patients with IgA nephropathy. (C) 1998 Wiley-Liss, Inc.
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页码：1 / 5
页数：5
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