Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis(hydroxymethyl)-1-methyl-7- and 7,8-substituted-benzo[g]indoles

被引：8
|
作者：
Pinna, GA [1 ]
Pirisi, MA [1 ]
Sechi, M [1 ]
Paglietti, G [1 ]
机构：
[1] Univ Sassari, Ist Chim Farmaceut & Tossicol, I-07100 Sassari, Italy
来源：
FARMACO | 1998年 / 53卷 / 02期
关键词：
benzo[g]indole biscarbamates; anticancer activity; cytotoxic activity; cytostatic activity;
D O I：
10.1016/S0014-827X(97)00016-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of various bis(hydroxymethyl) carbamate derivatives of 7-mono- and 7,8-disubstituted-1-methyl-benzo[g]indoles was prepared in order to evaluate their cytostatic and cytotoxic activities in vitro. Compounds 2a-h showed significant tumor growth inhibition activity and were more potent than the 4,5-dihydrobenzo[g]indole analogues previously described. Compound 2a was the most active in this series, showing high activity and selectivity for some human cancer cell lines in the National Cancer Institute screen. (C) 1998 Elsevier Science S.A. All rights reserved.
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页码：161 / 168
页数：8
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