Catalytic Asymmetric Intramolecular Darzens Reaction of 2-Halomalonate Derivatives

被引：0

作者：

Kobayashi, Kenichi ^{[1
]}

Tanaka, Kosaku, III ^{[1
]}

Suzuki, Momoko ^{[1
]}

Kogen, Hiroshi ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Grad Sch Pharmaceut Sci, Kiyose, Tokyo 2048588, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 10期

关键词：

Darzens reaction; asymmetric synthesis; asymmetric catalyst; organocatalyst; intramolecular reaction; ENANTIOSELECTIVE SYNTHESIS;

D O I：

10.1177/1934578X19884409

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A catalytic asymmetric intramolecular Darzens reaction of 2-halomalonate derivatives was developed for the enantioselective preparation of chiral building blocks for epoxide-containing natural products. Among the screened catalysts, some phase-transfer catalysts gave the desired epoxide in moderate enantioselectivity, albeit in low yield. The epoxide product would be useful as versatile chiral building blocks for natural product synthesis.

引用

页数：6

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