Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function

被引：31

作者：

Santos, Gilberto Maia ^{[1
]}

Ismael, Shamila ^{[1
,2
,3
]}

Morais, Juliana ^{[1
,2
,3
]}

Araujo, Joao R. ^{[1
,2
]}

Faria, Ana ^{[1
,2
,3
]}

Calhau, Conceicao ^{[1
,2
,4
]}

Marques, Claudia ^{[1
,2
]}

机构：

[1] Univ NOVA Lisboa, NOVA Med Sch, Nutr & Metab, Fac Ciencias Med, P-1169056 Lisbon, Portugal

[2] Univ NOVA Lisboa, CINTESIS Ctr Hlth Technol Serv Res, Fac Ciencias Med, NOVA Med Sch, P-1169056 Lisbon, Portugal

[3] Univ NOVA Lisboa, CHRC Comprehens Hlth Res Ctr, CEDOC Chron Dis Res Ctr, NOVA Med Sch,Fac Ciencias Med, P-1169056 Lisbon, Portugal

[4] NOVA Med Sch, Unidade Univ Lifestyle Med Jose Mello Saude, P-1169056 Lisbon, Portugal

来源：

MICROORGANISMS | 2022年 / 10卷 / 04期

关键词：

inflammatory bowel disease; intestinal alkaline phosphatase; intestinal barrier function; low-grade chronic inflammation; metabolic dysfunction; necrotizing enterocolitis; obesity; BRUSH-BORDER MEMBRANE; PHYSIOLOGICAL PH RANGE; CHAIN FATTY-ACIDS; METABOLIC SYNDROME; NECROTIZING ENTEROCOLITIS; LIPID-COMPOSITION; GUT MICROBIOTA; DIETARY FIBER; INFLAMMATION; PERMEABILITY;

D O I：

10.3390/microorganisms10040746

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.

引用

页数：15

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