β-Cyclodextrin derivatives hybrid Fe3O4 magnetic nanoparticles as the drug delivery for ketoprofen

beta-Cyclodextrin (beta-CD) and its derivatives carboxymethyl-beta-CD (CM-beta-CD) and 2,6-dimethyl-beta-CD (DM-beta-CD) modified magnetic nanoparticles (CD-MNPs) were synthesized via layer-by-layer method. CDs grafted onto Fe3O4 MNPs were demonstrated by transmission electron microscopy, Fourier transform infrared and Zeta potential. Magnetic properties of CM-beta-CD-MNPs, DM-beta-CD-MNPs and beta-CD-MNPs were characterized by vibrating sample magnetometer and the magnetic saturation values were 47, 46 and 44 emu g(-1), respectively. CD-MNPs as drug carriers were investigated by inclusion behavior and in vitro release using ketoprofen (KP) as a model drug. The maximum adsorption quantities of CM-beta-CD-MNPs, DM-beta-CD-MNPs and beta-CD-MNPs for KP were 37.03, 7.63 and 25.12 mg g(-1), respectively, and the loading behaviors followed the Langmuir adsorption isotherm model with monolayer adsorption. The release profiles of KP released from KP-loaded CD-MNPs were rapid in initial 60 min and then gradually tend to level off, the release efficiency order was CM-beta-CD-MNPs[beta-CD-MNPs > DM-beta-CD-MNPs, which was consistent with the order of inclusion capability. Therefore, the CD-MNPs were promising candidates for drug delivery.