Biophysical characterization of the complexation of C60 fullerene with doxorubicin in a prokaryotic model

被引：10
|
作者：
Prylutskyy, Y. [1 ]
Borowik, A. [2 ]
Golunski, G. [2 ]
Woziwodzka, A. [2 ]
Piosik, J. [2 ]
Kyzyma, O. [1 ,3 ]
Pashkova, I. [4 ]
Ritter, U. [5 ]
Evstigneev, M. [4 ,6 ]
机构：
[1] Taras Shevchenko Natl Univ Kyiv, Volodymyrska Str 64, UA-01601 Kiev, Ukraine
[2] Intercollegiate Fac Biotechnol UG MUG, Biophys Lab, Kladki 24, PL-80822 Gdansk, Poland
[3] Joint Inst Nucl Res, Joliot Curie Str 6, Dubna 141980, Moscow Region, Russia
[4] Sevastopol State Univ, Dept Phys, Univ Str 33, Sevastopol 299053, Ukraine
[5] Tech Univ Ilmenau, Inst Chem & Biotechnol, Weimarer Str 25, D-98693 Ilmenau, Germany
[6] Belgorod State Univ, Dept Biol & Chem, Pobedy Str 85, Belgorod 308015, Russia
来源：
MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK | 2016年 / 47卷 / 2-3期
关键词：
C-60; fullerene; doxorubicin; mutagenicity; small-angle neutron scattering; METHYLXANTHINES; PRISTINE; CAFFEINE; DNA;
D O I：
10.1002/mawe.201600463
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
By means of small-angle neutron scattering and ames mutagenicity test it was shown that C-60 fullerene may act as an interceptor of the antibiotic doxorubicin by formation of a hetero-complex with this drug. This result has been predicted based on previously developed model of chemico-biological interaction between DNA-binding drugs and aromatic interceptor molecules.
引用
收藏
页码：92 / 97
页数：6
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