Hemozoin: Malaria's "Built-In" Adjuvant and TLR9 Agonist

被引：8

作者：

Wagner, Hermann ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Med Mikrobiol Immunol & Hyg, D-81675 Munich, Germany

来源：

CELL HOST & MICROBE | 2010年 / 7卷 / 01期

关键词：

PARASITES;

D O I：

10.1016/j.chom.2010.01.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The "built-in" adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a "built-in" adjuvant.

引用

页码：5 / 6

页数：2

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