COMBINED TREATMENT WITH L-Citrulline and Tetrahydrobiopterin (BH4) Synergistically Ameliorates Chronic Hypoxia-Induced Pulmonary Hypertension in Newborn Pigs

被引：0
|
作者：
Fike, C. D. [1 ,2 ]
Kaplowitz, M. R. [1 ,2 ]
Aschner, J. L. [1 ,2 ]
机构：
[1] Univ Utah, Sch Med, Salt Lake City, UT USA
[2] Albert Einstein Coll Med, New York, NY USA
来源：
ACTA PAEDIATRICA | 2017年 / 106卷
关键词：
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
引用
收藏
页码：12 / 13
页数：2
相关论文
共 50 条
  • [1] Combined L-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
    Dikalova, Anna
    Aschner, Judy L.
    Kaplowitz, Mark R.
    Cunningham, Gary
    Summar, Marshall
    Fike, Candice D.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2020, 318 (04) : L762 - L772
  • [2] L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets
    Ananthakrishnan, Madhumita
    Barr, Frederick E.
    Summar, Marshall L.
    Smith, Heidi A.
    Kaplowitz, Mark
    Cunningham, Gary
    Magarik, Jordan
    Zhang, Yongmei
    Fike, Candice D.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 297 (03) : L506 - L511
  • [3] Rescue Treatment with L-Citrulline Inhibits Hypoxia-Induced Pulmonary Hypertension in Newborn Pigs
    Fike, Candice D.
    Dikalova, Anna
    Kaplowitz, Mark R.
    Cunningham, Gary
    Summar, Marshall
    Aschner, Judy L.
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2015, 53 (02) : 255 - 264
  • [4] Folic acid, either solely or combined with L-citrulline, improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
    Douglass, Matthew
    Dikalova, Anna
    Kaplowitz, Mark R.
    Zhang, Yongmei
    Cunningham, Gary
    Summar, Marshall
    Fike, Candice D.
    PHYSIOLOGICAL REPORTS, 2021, 9 (21):
  • [5] L-Citrulline Inhibits Chronic Hypoxia-Induced Pulmonary Hypertension in Newborn Piglets
    Fike, Candice
    Ananthakrishnan, Madhumita
    Kaplowitz, Mark
    Barr, Frederick
    Summar, Marshall
    FASEB JOURNAL, 2008, 22
  • [6] Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
    Dikalova, Anna
    Aschner, Judy L.
    Kaplowitz, Mark R.
    Summar, Marshall
    Fike, Candice D.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 311 (04) : L743 - L753
  • [7] Combined treatment with L-citrulline and tetrahydrobiopterin (BH4,) synergistically improves nitric oxide (NO) signalling in hypoxic piglet pulmonary arterial endothelial cells (PAECs)
    Fike, C. D.
    Dikalova, A.
    Zhang, Y.
    Aschner, J. L.
    PEDIATRIC RESEARCH, 2016, 80 (04) : 623 - 624
  • [8] Tetrahydrobiopterin (BH4) in Normal Fetal Development and Hypoxia-Induced Hypertonic Newborn Rabbits
    Vasquez-Vivar, Jeannette
    Whitsett, Jennifer
    Yu, Lei
    Derrick, Matthew
    Ji, Xinhai
    Tan, Sidhartha
    FREE RADICAL BIOLOGY AND MEDICINE, 2008, 45 : S107 - S107
  • [9] l-Citrulline treatment alters the structure of the pulmonary circulation in hypoxic newborn pigs
    McClellan, Eric B.
    Wang, Zhengming
    Albertine, Kurt H.
    Kaplowitz, Mark R.
    Zhang, Yongmei
    Fike, Candice D.
    PEDIATRIC PULMONOLOGY, 2020, 55 (10) : 2762 - 2772
  • [10] Lack of evidence for a role of BH4/BH2-dependent eNOS uncoupling in hypoxia-induced pulmonary hypertension
    Dubois, M.
    Delannoy, E.
    Duluc, L.
    Closs, E.
    Huige, L.
    Gadeau, A. P.
    Freund-Michel, V.
    Courtois, A.
    Marthan, R.
    Savineau, J. P.
    Muller, B.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2012, 26 : 19 - 19
12345