Bone Health in Idiopathic Inflammatory Myopathies: Diagnosis and Management
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作者:
Vincze, Anett
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Univ Debrecen, Fac Med, Div Clin Immunol, Moricz Zsigmond Ut 22, H-4032 Debrecen, Hungary
Univ Debrecen, Gyula Petranyi Doctoral Sch Clin Immunol & Allerg, Debrecen, HungaryUniv Debrecen, Fac Med, Div Clin Immunol, Moricz Zsigmond Ut 22, H-4032 Debrecen, Hungary
Vincze, Anett
[1
,2
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Gaal, Janos
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Univ Debrecen, Fac Med, Div Clin Immunol, Moricz Zsigmond Ut 22, H-4032 Debrecen, Hungary
Univ Debrecen, Gyula Petranyi Doctoral Sch Clin Immunol & Allerg, Debrecen, Hungary
Univ Debrecen, Kenezy Gyula Univ Hosp, Dept Med, Debrecen, HungaryUniv Debrecen, Fac Med, Div Clin Immunol, Moricz Zsigmond Ut 22, H-4032 Debrecen, Hungary
Gaal, Janos
[1
,2
,3
]
Griger, Zoltan
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Univ Debrecen, Fac Med, Div Clin Immunol, Moricz Zsigmond Ut 22, H-4032 Debrecen, Hungary
Univ Debrecen, Gyula Petranyi Doctoral Sch Clin Immunol & Allerg, Debrecen, HungaryUniv Debrecen, Fac Med, Div Clin Immunol, Moricz Zsigmond Ut 22, H-4032 Debrecen, Hungary
Griger, Zoltan
[1
,2
]
机构:
[1] Univ Debrecen, Fac Med, Div Clin Immunol, Moricz Zsigmond Ut 22, H-4032 Debrecen, Hungary
Purpose of Review This article provides an update on the most recent advances in epidemiology, pathogenesis, diagnostic procedures, and therapeutic approaches for myositis-associated bone diseases, such as osteoporosis and bone fractures. Recent Findings In the recent years, several studies showed that osteoporosis and consequent fractures are a common and frequently underestimated complication in patients with idiopathic inflammatory myopathies (IIM). In younger patients, asymptomatic fractures might present in the early phase of the disease which could increase the risk of development of further fractures. High-risk patients could be selected with early application of combined diagnostic procedures, such as fracture risk scores with steroid dose adjustments and imaging. Recent advances might help clinicians from different fields of medicine in the early recognition and management of myositis-associated osteoporosis, which will potentially improve the quality of life of patients with IIM.
机构:
Karolinska Inst, Rheumatol Unit, Dept Med, Karolinska Univ Hosp, Stockholm, SwedenKarolinska Inst, Rheumatol Unit, Dept Med, Karolinska Univ Hosp, Stockholm, Sweden
Lundberg, I. E.
Miller, F. W.
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NIEHS, NIH, Clin Res Ctr, Bethesda, MD USAKarolinska Inst, Rheumatol Unit, Dept Med, Karolinska Univ Hosp, Stockholm, Sweden
Miller, F. W.
Tjarnlund, A.
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Karolinska Inst, Rheumatol Unit, Dept Med, Karolinska Univ Hosp, Stockholm, SwedenKarolinska Inst, Rheumatol Unit, Dept Med, Karolinska Univ Hosp, Stockholm, Sweden
Tjarnlund, A.
Bottai, M.
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Karolinska Inst, Inst Environm Med, Stockholm, SwedenKarolinska Inst, Rheumatol Unit, Dept Med, Karolinska Univ Hosp, Stockholm, Sweden
机构:
Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14215Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14215