Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002-2014: a multicentre retrospective cross-sectional study

被引：55

作者：

Leblebicioglu, H. ^{[1
]}

Sunbul, M. ^{[1
]}

Guner, R. ^{[2
]}

Bodur, H. ^{[3
]}

Bulut, C. ^{[4
]}

Duygu, F. ^{[5
]}

Elaldi, N. ^{[6
]}

Senturk, G. Cicek ^{[7
]}

Ozkurt, Z. ^{[8
]}

Yilmaz, G. ^{[9
]}

Fletcher, T. E. ^{[1
,10
]}

Beeching, N. J. ^{[10
,11
]}

机构：

[1] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey

[2] Yildirim Beyazit Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[3] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[4] Ankara Res & Training Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[5] Gaziosmanpasa Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Tokat, Turkey

[6] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey

[7] SB Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[8] Ataturk Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey

[9] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey

[10] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

[11] Univ Liverpool, NIHR HPRU Emerging & Zoonot Infect, Liverpool L69 3BX, Merseyside, England

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2016年 / 22卷 / 04期

基金：

英国惠康基金;

关键词：

Crimean-Congo haemorrhagic fever; healthcare associated; infection prevention and control; ribavirin; viral haemorrhagic fever; NOSOCOMIAL TRANSMISSION; RIBAVIRIN; PROPHYLAXIS; VIRUS;

D O I：

10.1016/j.cmi.2015.11.024

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：387.e1 / 387.e4

页数：4

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