Sol-gel processing of drug delivery materials and release kinetics

被引：46
|
作者：
De Gaetano, F [1 ]
Ambrosio, L [1 ]
Raucci, MG [1 ]
Marotta, A [1 ]
Catauro, M [1 ]
机构：
[1] Univ Naples Federico II, Dept Mat & Prod Engn, I-80125 Naples, Italy
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2005年 / 16卷 / 03期
关键词：
D O I：
10.1007/s10856-005-6688-x
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Silica, calcium ( 5 mol%) silicate and silica/polycaprolactone hybrid inorganic/organic amorphous materials, all mixed with sodium ampicillin, a broad-spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature of the gels was ascertained by X-ray diffraction analysis. Release kinetics in a simulate body fluid (SBF) have been subsequently investigated. The amount of sodium ampicillin released has been detected by UV-Vis spectroscopy and SEM. The release kinetics seems to occur in more than one stage. Finally FTIR measurements and SEM micrograph showed the formation of a hydroxyapatite layer on the surface of the samples soaked in SBF. All data showed that these materials could be used as drug delivery bioactive systems. (C) 2005 Springer Science + Business Media, Inc.
引用
收藏
页码：261 / 265
页数：5
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