The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer's Disease

被引：26
|
作者：
Cellai, Lucrezia [1 ]
Carvalho, Kevin [1 ]
Faivre, Emilie [1 ]
Deleau, Aude [1 ]
Vieau, Didier [1 ]
Buee, Luc [1 ]
Blum, David [1 ]
Meriaux, Celine [1 ]
Gomez-Murcia, Victoria [1 ]
机构：
[1] Univ Lille, CHU Lille, INSERM, JPArc,LabEx DISTALZ,UMR S 1172, Lille, France
来源：
FRONTIERS IN NEUROSCIENCE | 2018年 / 12卷
关键词：
Alzheimer's disease; memory; caffeine; adenosine; adenosine receptors; A(2A) RECEPTOR BLOCKADE; BETA-AMYLOID PEPTIDES; ATP RELEASE; EXTRACELLULAR ADENOSINE; NUCLEOSIDE TRANSPORTERS; COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; MOTOR FLUCTUATIONS; CAFFEINE PROTECTS; GLUTAMATE UPTAKE;
D O I：
10.3389/fnins.2018.00520
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated beta-amyloid (A beta) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics.
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页数：9
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