Spectrofluorimetric determination of levofloxacin in tablets, human urine and serum

被引：78
|
作者：
González, JAO [1 ]
Mochón, MC [1 ]
de la Rosa, FJB [1 ]
机构：
[1] Univ Seville, Fac Chem, Dept Analyt Chem, E-41012 Seville, Spain
来源：
TALANTA | 2000年 / 52卷 / 06期
关键词：
levofloxacin determination; micelle enhanced fluorescence; urine; serum; pharmaceutical tablets;
D O I：
10.1016/S0039-9140(00)00484-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A spectrofluorimetric method to determine levofloxacin is proposed and applied to determine the substance in tablets and spiked human urine and serum. The fluorimetric method allow the determination of 20-3000 ng ml(-1) of levofloxacin in aqueous solution containing acetic acid-sodium acetate buffer (pH 4) with lambda (exc) = 292 and lambda (em) = 494 nm, respectively. Micelle enhanced fluorescence improves the sensibility and allows levofloxacin direct measurement in spiked Human serum (5 mug ml(-1)) and urine (420 mug ml(-1)), in 8 mM sodium dodecyl sulphate solutions at pH 5. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：1149 / 1156
页数：8
相关论文
共 50 条
  • [1] Spectrofluorimetric determination of moxifloxacin in tablets, human urine and serum
    Ocaña, JA
    Barragán, FJ
    Callejón, M
    ANALYST, 2000, 125 (12) : 2322 - 2325
  • [2] SPECTROFLUORIMETRIC DETERMINATION OF LEVOFLOXACIN IN PHARMACEUTICALS AND IN HUMAN URINE
    Da Silva, Arnaldo Peixoto
    Luna, Aderval Severino
    Da Silva Costa, Thais Malcher
    Aucelio, Ricardo Queiroz
    Batista Braga, Jez Willian
    Boque, Ricard
    Ferre, Joan
    INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2012, 2 (01): : P147 - P158
  • [3] Terbium-sensitized luminescence determination of levofloxacin in tablets and human urine and serum
    Ocaña, JA
    Callejón, M
    Barragán, FJ
    ANALYST, 2000, 125 (10) : 1851 - 1854
  • [4] Spectrofluorimetric and micelle-enhanced spectrofluorimetric determination of gatifloxacin in human urine and serum
    Ocaña, JA
    Barragán, FJ
    Callejón, M
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 37 (02) : 327 - 332
  • [5] Flow injection spectrophotometric determination of the antibacterial levofloxacin in tablets and human urine
    Al-Momani, IF
    ANALYTICAL LETTERS, 2006, 39 (04) : 741 - 750
  • [6] Evaluation of a spectrofluorimetric method for the selective determination of thalidomide in pharmaceutical tablets, urine and blood serum
    Cardoso, CE
    Martins, ROR
    Aucelio, RQ
    MICROCHEMICAL JOURNAL, 2004, 77 (01) : 1 - 7
  • [7] Spectrofluorimetric determination of ondansetron in pharmaceutical tablets: Applicability to human urine and content uniformity testing
    Gayatri, Sambhani Naga
    Palle, Kishor
    Susmitha, T.
    Yumnam, Sujata
    Kumar, Narendra Phani
    MATERIALS TODAY-PROCEEDINGS, 2022, 64 : 79 - 82
  • [8] Spectrofluorimetric determination of ondansetron in pharmaceutical tablets: Applicability to human urine and content uniformity testing
    Gayatri, Sambhani Naga
    Palle, Kishor
    Susmitha, T.
    Yumnam, Sujata
    Kumar, Narendra Phani
    MATERIALS TODAY-PROCEEDINGS, 2022, 64 : 79 - 82
  • [9] Colorimetric and spectrofluorimetric methods for the determination of melatonin in tablets and serum
    Gazy, AA
    Abdine, HH
    Abdel-Hay, MH
    SPECTROSCOPY LETTERS, 1998, 31 (01) : 177 - 197
  • [10] Micellar-enhanced spectrofluorimetric determination of trazodone hydrochloride in human urine and serum
    Yang, Gong-Jun
    Liu, Ping
    Qu, Xi-Long
    Ming-Shen
    Wang, Chen-Ying
    Qu, Qi-Shu
    Hu, Xiao-Ya
    Leng, Zong-Zhou
    ANALYTICAL LETTERS, 2007, 40 (01) : 151 - 162
12345