Dual ligand engagement for noncanonical inflammasome activation

被引：4
|
作者：
Yang, Zhang-Hua [1 ]
Han, Jiahuai [1 ]
机构：
[1] Xiamen Univ, Sch Med, Canc Res Ctr, Res Unit Cellular Stress,Chinese Acad Med Sci, Xiamen, Peoples R China
来源：
NATURE IMMUNOLOGY | 2022年 / 23卷 / 05期
关键词：
GASDERMIN D; CASPASES; RNA;
D O I：
10.1038/s41590-022-01188-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.
引用
收藏
页码：651 / 653
页数：3
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