High-throughput hit-squad tackles trypanosomes

被引:1
|
作者
Cook, Alexander D. [1 ]
Higgins, Matthew K. [1 ]
机构
[1] Univ Oxford, Dept Biochem, Oxford, England
基金
英国惠康基金;
关键词
D O I
10.1016/j.pt.2021.07.005
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
African trypanosomes cause diseases of humans and their livestock. To date, a much-desired vaccine has been elusive, due in part to the immune evasion mechanisms of these cunning parasites. However, Autheman et al. have used a bold, high-throughput screen to provide hope that vaccines may be on the way.
引用
收藏
页码:772 / 774
页数:3
相关论文
共 50 条
  • [1] TEBBIT TOLD TO LEAD EXPORTS HIT-SQUAD
    WYMAN, V
    ENGINEER, 1985, 260 (6736) : 10 - 10
  • [2] NORTHERN-IRELAND HIT-SQUAD SCANDAL
    FLANDERS, L
    NATION, 1989, 249 (14) : 491 - 494
  • [3] Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification
    Sutanto, Fandi
    Shaabani, Shabnam
    Oerlemans, Rick
    Eris, Deniz
    Patil, Pravin
    Hadian, Mojgan
    Wang, Meitian
    Sharpe, May Elizabeth
    Groves, Matthew R.
    Domling, Alexander
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (33) : 18231 - 18239
  • [4] High-throughput cytotoxicity screening: hit and miss
    Crouch, SPM
    Slater, KJ
    DRUG DISCOVERY TODAY, 2001, 6 (12) : S48 - S53
  • [5] Applications of Biophysics in High-Throughput Screening Hit Validation
    Genick, Christine Clougherty
    Barlier, Danielle
    Monna, Dominique
    Brunner, Reto
    Be, Celine
    Scheufler, Clemens
    Ottl, Johannes
    JOURNAL OF BIOMOLECULAR SCREENING, 2014, 19 (05) : 707 - 714
  • [6] Hit and lead generation:: Beyond high-throughput screening
    Bleicher, KH
    Böhm, HJ
    Müller, K
    Alanine, AI
    NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) : 369 - 378
  • [7] Hit and lead generation: beyond high-throughput screening
    Konrad H. Bleicher
    Hans-Joachim Böhm
    Klaus Müller
    Alexander I. Alanine
    Nature Reviews Drug Discovery, 2003, 2 : 369 - 378
  • [8] VAPPER: High-throughput variant antigen profiling in African trypanosomes of livestock
    Pereira, Sara Silva
    Heap, John
    Jones, Andrew R.
    Jackson, Andrew P.
    GIGASCIENCE, 2019, 8 (09):
  • [9] Improved statistical methods for hit selection in high-throughput screening
    Brideau, C
    Gunter, B
    Pikounis, B
    Liaw, A
    JOURNAL OF BIOMOLECULAR SCREENING, 2003, 8 (06) : 634 - 647
  • [10] High-throughput hit identification with acoustic ejection mass spectrometry
    Wen, Xiujuan
    Mclaren, David G.
    SLAS TECHNOLOGY, 2025, 31