Effects of GABAA/ω/Cl- agonists on body weight in isolated male mice

Numerous studies have demonstrated that GABA(A)/omega/Cl- receptor agonists may increase body weight in grouped rodents. However, there is no evidence in relation to the possible actions of these drugs under isolation conditions. In this study, we examine the acute and subchronic effects of several doses of benzodiazepines (diazepam, clobazam, bentazepam and midazolam), cyclopyrrolones (zopiclone) and imidazopyridines (zolpidem) on body weight in isolated male mice. All animals were housed individually in ges during 30 days (non-drug period) and weighted weekly. After isolation period, drugs were administered acutely or daily for 10 consecutive days and body weights measured. Results showed that benzodiazepines, cyclopyrrolones and imidazopyridines did not vary significantly body weight, as compared with their saline groups, It is concluded that housing conditions can play a critical role in the modulation of GABA(A)/omega/Cl- receptor agonists actions on body weight in mice.