Palliative and adjuvant regional chemotherapy in pancreatic cancer

被引:46
|
作者
Link, KH
Gansauge, F
Gorich, J
Leder, GH
Rilinger, N
Beger, HG
机构
[1] UNIV ULM, DEPT GEN SURG, D-89075 ULM, GERMANY
[2] UNIV ULM, DEPT RADIOL 1, D-89075 ULM, GERMANY
来源
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY | 1997年 / 23卷 / 05期
关键词
chemotherapy; pancreas; cancer; coeliac artery infusion; therapy;
D O I
10.1016/S0748-7983(97)93720-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To improve the dismal prognosis of patients (pts) with pancreatic cancer we treated 32 patients with non-resectable (UICC LII, 17 pts; UICC IC 15 pts-group 1) and 20 patients with resected (UICC I, 1 pt; UICC II, 3 pts; UICC III, 16 pts-group 2) pancreatic cancer with palliative (group I) and adjuvant post-operative (group II) coeliac axis intra-arterial cyclic infusions (CAI), CAI consisted of mitoxantrone 10 mg/m(2) on day 1, folinic acid 170 mg/m(2) and 5-FU 600 mg/m(2) during days 2-4, and cis-platinum 60 mg/m(2) on day 5 for up to 11 (group I) or six (group II) cycles, In a total of 211 cycles toxicities at the level of WHO III occurred in 0-6% and of WHO IV in 0%, The median survival times, compared with institutional historical controls (treated vs controls), were 12 vs 4.8 months in UICC III (P < 0.006) and 4 vs 2.9 months in UICC IV (P < 0.05) group I pts, and 21 vs 9.3 months in group II (P < 0.0003), Hepatic disease progression appeared to be suppressed with CAI, which also appears to be effective for palliative and adjuvant treatment in non-resectable and resected pancreatic cancer.
引用
收藏
页码:409 / 414
页数:6
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