Formulation, Physicochemical Characterization, and In Vitro Study of Chitosan/HPMC Blends-Based Herbal Blended Patches

被引:30
|
作者
Suksaeree, Jirapornchai [1 ,2 ,3 ]
Monton, Chaowalit [2 ,3 ]
Madaka, Fameera [2 ,3 ]
Chusut, Tun [2 ,3 ]
Saingam, Worawan [2 ,3 ]
Pichayakorn, Wiwat [4 ,5 ]
Boonme, Prapaporn [4 ]
机构
[1] Rangsit Univ, Dept Pharmaceut Chem, Fac Pharm, Muang 12000, Pathum Thani, Thailand
[2] Harbin Inst Technol, Sinothai Tradit Med Res Ctr, Harbin, Peoples R China
[3] Rangsit Univ, Fac Pharm, Muang 12000, Pathum Thani, Thailand
[4] Prince Songkla Univ, Fac Pharmaceuti cal Sci, Dept Pharmaceut Technol, Hat Yai 90112, Songkhla, Thailand
[5] Prince Songkla Univ, Med Prod Innovat Polymers Clin Use Res Unit, Hat Yai 90112, Songkhla, Thailand
来源
AAPS PHARMSCITECH | 2015年 / 16卷 / 01期
关键词
chitosan; formulation; herbal blended patches; HPMC; Zingiber cassumunar Roxb; TOPICAL ANTIINFLAMMATORY ACTIVITY; MAJOR LIPOPHILIC CONSTITUENTS; ZINGIBER-CASSUMUNAR; CONTROLLED-RELEASE; BIODEGRADABLE POLYMERS; DRUG; NANOPARTICLES; MICROSPHERES; FABRICATION; RHIZOMES;
D O I
10.1208/s12249-014-0216-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The current work prepared chitosan/hydroxypropyl methylcellulose (HPMC) blends and studied the possibility of chitosan/HPMC blended patches for Zingiber cassumunar Roxb. The blended patches without/with crude Z. cassumunar oil were prepared by homogeneously mixing the 3.5% w/v of chitosan solution and 20% w/v of HPMC solution, and glycerine was used as plasticizer. Then, they were poured into Petri dish and produced the blended patches in hot air oven at 70 +/- 2A degrees C. The blended patches were tested and evaluated by the physicochemical properties: moisture uptake, swelling ratio, erosion, porosity, Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction, and photographed the surface and cross-section morphology under SEM technique. Herbal blended patches were studied by the in vitro release and skin permeation of active compound D. The blended patches could absorb the moisture and became hydrated patches that occurred during the swelling of blended patches. They were eroded and increased by the number of porous channels to pass through out for active compound D. In addition, the blended patches indicated the compatibility of the blended ingredients and homogeneous smooth and compact. The blended patches made from chitosan/HPMC blends provide a controlled release and skin permeation behavior of compound D. Thus, the blended patches could be suitably used for herbal medicine application.
引用
收藏
页码:171 / 181
页数:11
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