Asbestos exposure and antineutrophil cytoplasmic antibody (ANCA) positivity

被引:21
|
作者
Pelclová, D
Bartunková, J
Fenclová, Z
Lebedová, J
Hladíková, M
Benáková, H
机构
[1] Charles Univ Prague, Dept Occupat Med, Fac Med 1, Prague 12000, Czech Republic
[2] Gen Teaching Hosp, Inst Clin Biochem, Prague 12000, Czech Republic
[3] Charles Univ Prague, Fac Med 2, Dept Med Informat, Prague 12000, Czech Republic
[4] Charles Univ Prague, Fac Med 2, Inst Immunol, Prague 12000, Czech Republic
来源
ARCHIVES OF ENVIRONMENTAL HEALTH | 2003年 / 58卷 / 10期
关键词
antibodies; asbestos; Czech Republic; occupational health;
D O I
10.3200/AEOH.58.10.662-668
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The authors used indirect immunofluorescence to examine the association of antineutrophil cytoplasmic antibodies (ANCAs) with exposure to asbestos among 61 asbestos-exposed patients (mean exposure = 24.6 yr) and 39 nonexposed controls. ANCA positivity was detected significantly more frequently (p = 0.034) in the asbestos-ex posed group (21.3%) than in the control group (5.1%). ANCA-associated diseases did not occur more frequently among subjects exposed previously to asbestos than among unexposed controls. These findings confirmed that exposure to asbestos is another occupational factor, as is silica exposure, that is associated with ANCA positivity. The influence of asbestos appears stronger than that of silica because ANCA positivity was found among subjects who had histories of exposure to asbestos but who did not exhibit typical radiographic signs of asbestosis on their chest x-rays. Additional stimuli may be necessary to induce systemic vasculitis in asbestos-ex posed persons.
引用
收藏
页码:662 / 668
页数:7
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