Public attention to sexual assault has increased dramatically over the last decade, spurring questions about how it can be prevented. One approach that has received scant attention is women's self-defense training (sometimes known as sexual assault resistance training). This neglect is curious because empowerment-based women's self-defense (ESD) training is so far the only approach that has produced substantively significant decreases in victimization rates. In this article, I review the research evidence on women's self-defense training. Does resisting a sexual assault affect the outcome of sexual violence? Does self-defense training further reduce women's risk of violence? What are the other consequences of self-defense training? How does self-defense work for different groups of womenfor example, those who have survived prior victimizations? Are the critiques of women's self-defense training valid? Finally, what do we still need to learn about women's self-defense? Overall, I argue that this evidence presents a compelling case that women's self-defense training should be central to any efforts to prevent sexual violence.