Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

被引：352
|
作者：
Rao, RV [1 ]
Bredesen, DE [1 ]
机构：
[1] Buck Inst Age Res, Novato, CA 94945 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 06期
关键词：
D O I：
10.1016/j.ceb.2004.09.012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The accumulation of misfolded proteins (e.g. mutant or damaged proteins) triggers cellular stress responses that protect cells against the toxic buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins induces specific death pathways. Dissecting these pathways should be valuable in understanding the pathogenesis of, and ultimately in designing therapy for, neurodegenerative diseases that feature misfolded proteins.
引用
收藏
页码：653 / 662
页数：10
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