Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients

被引：4
|
作者：
Tjin, Esther P. M. [1 ]
Luiten, Rosalie M. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Dermatol, NL-1105 AZ Amsterdam, Netherlands
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 09期
关键词：
clinical outcome; immunotherapy; immune-escape mechanisms; melanoma; tumor-infiltrating T-cells; LYMPHOCYTES; EXPRESSION; APOPTOSIS;
D O I：
10.4161/21624011.2014.954862
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of advanced melanoma patients to subsequent autologous tumor cell vaccination. Our data emphasize the therapeutic relevance of tumor-infiltrating T cells for the clinical outcome.
引用
收藏
页码：1 / 3
页数：3
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