Properties of cytochrome P450 isoenzymes and their substrates .2. properties of cytochrome P450 substrates

被引：107

作者：

Smith, DA

Ackland, MJ

Jones, BC

机构：

[1] Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent

来源：

DRUG DISCOVERY TODAY | 1997年 / 2卷 / 11期

关键词：

D O I：

10.1016/S1359-6446(97)01085-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cytochrome P450 isoenzymes are pivotal in drug clearance. Part 1 of this two-part review, published in the October issue of Drug Discovery Today, described the active site characteristics of members of the P450 superfamily. This article describes the great increase in our understanding of the substrate requirements of the human cytochrome P450 family and highlights the relevance of this knowledge for the design of new therapeutic agents.

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页码：479 / 486

页数：8

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