Systems biology of lipid metabolism: From yeast to human

被引：85

作者：

Nielsen, Jens ^{[1
]}

机构：

[1] Chalmers Univ Technol, Dept Chem & Biol Engn, SE-41296 Gothenburg, Sweden

来源：

FEBS LETTERS | 2009年 / 583卷 / 24期

关键词：

Systems biology; Lipid metabolism; Yeast; Metabolic model; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTORS; PHOSPHOLIPID BIOSYNTHESIS; NETWORKS REVEALS; FATTY-ACID; RECONSTRUCTION; MODELS; GENE; VALIDATION; EXPRESSION;

D O I：

10.1016/j.febslet.2009.10.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3905 / 3913

页数：9

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