The role of TNF-α induced protein 1 in the activation of pro-apoptotic proteins

被引：5
|
作者：
Tang, Xiaoren [1 ]
Tangkham, Thanarut [1 ]
Aljahdali, Bushra [1 ]
Lee, Sean [1 ]
Su, Mingfang [1 ]
Dibart, Serge [1 ]
机构：
[1] Boston Univ, Dept Periodontol, Henry M Goldman Sch Dent Med, 650 Albany St, Boston, MA 02215 USA
来源：
HUMAN CELL | 2021年 / 34卷 / 04期
关键词：
TNFAIP1; LPS-induced pathway; Protein Assay; Apoptotic genes;
D O I：
10.1007/s13577-021-00529-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It is known that Porphyromonas gingivalis/lipopolysaccharide (P. gingivalis/LPS) induces inflammatory diseases via TNF-alpha-mediated transcription factors. Our recent data shows that TNFAIP1 (TNF-alpha induced protein 1) is related to TNF-alpha. However, little is known regarding how TNFAIP1 is involved in the TNF-alpha-dependent pathway. We therefore focused on the biological function of TNFAIP1 and examined how TNFAIP1 mediates TNF-alpha and other genes. We found that TNF-alpha was upregulated and peaks before the upregulation of apoptotic genes such as Bad, Bcl-x, Caspase 3, Catalase, Claspin, Cytochromic, Ho-1/HMOX1/HSP32, or MCI-1 in our time course with TNFAIP1-treated cells. Our findings here may serve as the foundation for future studies linking regulation of TNFAIP1 and intervention of inflammatory disease.
引用
收藏
页码：1123 / 1129
页数：7
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