Advances in absolute protein quantification and quantitative protein mapping using ICP-MS

被引：41
|
作者：
Cid-Barrio, Laura [1 ]
Calderon-Celis, Francisco [1 ]
Abasolo-Linares, Patricia [1 ]
Luisa Fernandez-Sanchez, M. [1 ]
Manuel Costa-Fernandez, Jose [1 ]
Ruiz Encinar, Jorge [1 ]
Sanz-Meder, Alfredo [1 ]
机构：
[1] Univ Oviedo, Fac Chem, Dept Phys & Analyt Chem, Julian Claveria 8, E-33006 Oviedo, Spain
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2018年 / 104卷
关键词：
ICP-MS; Absolute quantification; Elemental labelling; Heteroatom tag; Laser ablation; Mass spectrometry; Targeted proteomics; PLASMA-MASS SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; ISOTOPE-DILUTION ANALYSIS; OF-THE-ART; ACCURATE QUANTIFICATION; GEL-ELECTROPHORESIS; SPECIATION ANALYSIS; CONTAINING PEPTIDES; BIOLOGICAL SAMPLES; TISSUE-SECTIONS;
D O I：
10.1016/j.trac.2017.09.024
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Protein and peptide detection with inductively coupled plasma mass spectrometry (ICP-MS) can provide their direct and reliable absolute quantification without the need for specific standards, which greatly complements molecular mass spectrometry features in proteomics. We discuss recent research to shed new light on this particular surge in the analytical applicability of ICP-MS and identify possible niches that could attract future analytical activity within this emerging field. (C) 2017 Published by Elsevier B.V.
引用
收藏
页码：148 / 159
页数：12
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