Rates of and reasons for failure of commercial human immunodeficiency virus type 1 viral load assays in Brazil

被引：24
|
作者：
Drexler, Jan Felix
de Souza Luna, Luciano Kleber
Pedroso, Celia
Pedral-Sampaio, Diana Brasil
Queiroz, Artur T. L.
Brites, Carlos
Netto, Eduardo M.
Drosten, Christian
机构：
[1] Bernhard Nocht Inst Trop Med, Clin Virol Sect, D-20359 Hamburg, Germany
[2] Hosp Univ Prof Edgard Santos, Lab Pesquisa Infectol, Salvador, BA, Brazil
[3] Fiocruz MS, Lab Saude Avancada, Salvador, BA, Brazil
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2007年 / 45卷 / 06期
关键词：
D O I：
10.1128/JCM.00136-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We examined failures of commercial human immunodeficiency virus type 1 (HIV-1) viral load assays of 1,195 plasma samples from Brazilian patients. Assay failure was assumed for samples in which the virus was undetectable by commercial assay but which tested positive by real-time reverse transcription-PCR of the HIV-1 long terminal repeat (LTR) region or if the viral load differed by > 2 log(10) from that determined by LTR assay. Failure rates for Bayer Versant bDNA 3.0, Roche Amplicor Monitor v1.5, and bioMerieux NucliSens QT were 0.68, 0.47, and 4.33%, respectively. NucliSens may be inadequate for use in Brazil.
引用
收藏
页码：2061 / 2063
页数：3
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