SYNTHESIS AND SCREENING OF SOME NOVEL N-(4-OXO-2-SUBSTITUTED PHENYL-1,3-THIAZOLIDIN-3-YL)-1,3-BENZOXAZOLE-5-CARBOXAMIDE DERIVATIVES FOR ANTIBACTERIAL AND ANTITUBERCULAR ACTIVITIES

A novel Series of N-(4-oxo-2-substituted phenyl-1,3-thiazolidin-3-yl)-1,3-benzoxazole-5-carboxamide III (a-h) derivatives were synthesized by the reaction between Schiff bases of benzoxazole II (a-h) with thioglycollic acid. The purity of these compounds was confirmed by melting paint and TLC. Structure of these compounds was confirmed on the bases of IR, H-1 NMR, C-13 NMR and Mass spectral data. All the synthesized compounds were screened for their antibacterial and antitubercular activity using broth microdilution method and Microplate Alamar Blue Assay (MABA) method respectively. For antibacterial and antitubercular activities screening ciprofloxacin, norfloxacin and isoniazid were used as standard drugs respectively. The results showed that compounds III c, III d and III f exhibited good antibacterial activity and compounds III c, III f, III g and III h showed good antitubercular activity.