Five-year evolution of mild aortic regurgitation following transcatheter aortic valve implantation: early insights from a single-centre experience

被引:7
|
作者
Buzzatti, Nicola [1 ]
Castiglioni, Alessandro [1 ]
Agricola, Eustachio [2 ]
Barletta, Marta [2 ]
Stella, Stefano [2 ]
Giannini, Francesco [3 ]
Regazzoli, Damiano [3 ]
Mangieri, Antonio [3 ]
Ancona, Marco [3 ]
Spagnolo, Pietro [4 ]
Chieffo, Alaide [3 ]
Montorfano, Matteo [3 ]
Alfieri, Ottavio [1 ]
Colombo, Antonio [3 ]
Latib, Azeem [3 ]
机构
[1] Ist Sci San Raffaele, Dept Cardiac Surg, Via Olgettina 60, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, Dept Echocardiog, Milan, Italy
[3] Ist Sci San Raffaele, Dept Intervent Cardiol, Milan, Italy
[4] Ist Sci San Raffaele, Dept Radiol, Milan, Italy
关键词
TAVI; Mild; Regurgitation; Outcomes; INTERMEDIATE-RISK PATIENTS; REPLACEMENT; DISEASE; ECHOCARDIOGRAPHY; PREDICTORS; OUTCOMES;
D O I
10.1093/icvts/ivx070
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES: To assess the follow-up evolution and impact of mild aortic regurgitation (1 + AR) following transcatheter aortic valve implantation (TAVI). METHODS: We evaluated the follow-up outcomes and AR evolution of 558 patients affected by native aortic stenosis who underwent TAVI with residual AR <= 1+. RESULTS: No residual AR was found in 294 (52.7%) patients, whereas 1 + AR was found in 264 (47.3%) patients. At 5.5 years, freedom from all-cause mortality (56.9% vs 53.5%), cardiac mortality (75.0% vs 74.3%) and heart failure (70.0% vs 63.9%) were similar between no-AR and 1 + AR groups, respectively (all P > 0.05). New York Heart Association Class I-II was found in 88.9% vs 82.4% of patients respectively (P= 0.013). Freedom from AR >= 3+ at 5.5 years was 98.6% in the no-AR group vs 82.5% in the 1 + AR group (log-rank <0.001). Residual 1 + AR was found to be an independent predictor of increased follow-up AR >= 3+ (P = 0.012). In 1 + AR group, higher left ventricle mass index independently predicted increased cardiac death [ hazards ratio (HR) 1.01, confidence interval (CI) 1.00-1.02, P = 0.036] and heart failure rate (HR 1.01, CI 1.00-1.02, P = 0.002), while larger native aortic annulus perimeter predicted follow-up AR >= 3+ (HR 1.12, CI 1.02-1.22, P = 0.016). CONCLUSIONS: 5 years after TAVI, a higher progression of paravalvular AR to Grade >= 3+ together with worse symptoms were found in patients with residual 1 + AR compared with no-AR, although no marked difference in survival was observed. These findings raise further concerns about 1+ residual AR after TAVI, especially in the perspective of expanding indications to younger low-risk patients. Mechanisms that cause progression of paravalvular AR after TAVI remain to be clarified.
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页码:75 / 82
页数:8
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