Lipid rafts and signal transduction

被引：5076
作者：
Simons, K
Toomre, D
机构：
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
[2] European Mol Biol Lab, Cell Biol Biophys Programme, D-69117 Heidelberg, Germany
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2000年 / 1卷 / 01期
关键词：
D O I：
10.1038/35036052
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface - known as lipid rafts - also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades.
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收藏
页码：31 / 39
页数：9
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