αvβ integrins play an essential role in BMP-2 induction of osteoblast differentiation

被引：116
|
作者：
Lai, CF [1 ]
Cheng, SL [1 ]
机构：
[1] Washington Univ, Sch Med, Div Bone & Mineral Dis, Dept Internal Med, St Louis, MO 63110 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期
关键词：
integrins; bone morphogenetic protein-2; osteoblasts; proliferation; differentiation;
D O I：
10.1359/JBMR.041013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Both integrins and BMP-2 exert similar effects on osteoblasts. We examined the relationship between the alphav-containing integrins (alphavbeta) and BMP-2 in osteoblast function. BMP-2 stimulates alphavbeta expression. BMP-2 receptors co-localize/overlap with alphavbeta integrins, and the intact function of alphavbeta is essential in BMP-2 activity.
引用
收藏
页码：330 / 340
页数：11
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