Nucleic Acid Aptamers in Nanotechnology

被引：19

作者：

Sinitsyna, Valentina V. ^{[1
,2
]}

Vetcher, Alexandre A. ^{[1
,3
]}

机构：

[1] Peoples Friendship Univ Russia RUDN, Nanotechnol Sci & Educ Ctr, Inst Biochem Technol & Nanotechnol, Miklukho Maklaya St 6, Moscow 117198, Russia

[2] Russian Acad Sci 36, Shirshov Inst Oceanol, Moscow 117997, Russia

[3] Complementary & Integrat Hlth Clin Dr Shishonin 5, Yasnogorskaya St, Moscow 117588, Russia

来源：

BIOMEDICINES | 2022年 / 10卷 / 05期

关键词：

oligonucleotides; nucleic acids; nanotubes; nanobiosensors; aptamer aptasensor(s); BINDING DNA APTAMER; SELEX; ENZYMES; DIAGNOSIS; SELECTION; MOLECULE; DELIVERY;

D O I：

10.3390/biomedicines10051079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleic Acid (NA) aptamers are oligonucleotides. They are unique due to their secondary and tertiary structure; namely, the secondary structure defines the tertiary one by means of affinity and specificity. Our review is devoted only to DNA and RNA aptamers, since the majority of achievements in this direction were obtained with their application. NA aptamers can be used as macromolecular devices and consist of short single-stranded molecules, which adopt unique three-dimensional structures due to the interaction of complementary parts of the chain and stacking interactions. The review is devoted to the recent nanotechnological advances in NA aptamers application.

引用

页数：13

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