Authentic human milk oligosaccharides induce human tolerogenic Dendritic cells and consequently expand functional regulatory T vells via TLR4 and DC-SIGN signaling

被引:0
|
作者
Xiao, L. [1 ]
van de Worp, W. [1 ]
Stassen, R. [1 ]
Kettelarij, N. [2 ]
Stahl, B. [2 ]
Blijenberg, B. [2 ]
Overbeek, S. [1 ,2 ]
Folkerts, G. [1 ]
Garssen, J. [1 ,2 ]
van't Land, B. [2 ,3 ]
机构
[1] Univ Utrecht, UIPS, Utrecht, Netherlands
[2] Nutricia Res, Dept Immunol, Utrecht, Netherlands
[3] Wilhelmina Childrens Hosp, Univ Med Ctr Utrecht, Dept Pediat Immunol, Utrecht, Netherlands
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
P-292
引用
收藏
页码:185 / 186
页数:2
相关论文
共 16 条
  • [1] Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    van Stijn, Caroline M. W.
    Meyer, Sandra
    van den Broek, Marloes
    Bruijns, Sven C. M.
    van Kooyk, Yvette
    Geyer, Rudolf
    van Die, Irma
    MOLECULAR IMMUNOLOGY, 2010, 47 (7-8) : 1544 - 1552
  • [2] Induction of human tolerogenic dendritic cells by 3'-sialyllactose via TLR4 is explained by LPS contamination
    Perdijk, Olaf
    van Neerven, R. J. Joost
    Meijer, Ben
    Savelkoul, Huub F. J.
    Brugman, Sylvia
    GLYCOBIOLOGY, 2018, 28 (03) : 126 - 130
  • [3] Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells
    Gonzalez-Rey, E
    Chorny, A
    Fernandez-Martin, A
    Ganea, D
    Delgado, M
    BLOOD, 2006, 107 (09) : 3632 - 3638
  • [4] Targeting Dendritic Cells via the Dendritic Cell-Specific C Type Lectin DC-SIGN in Non-Human Primates: Towards a Novel Tolerogenic Cell-Specific Therapy
    Collins, M. G.
    Rogers, N. M.
    Kireta, S.
    Jesudason, S.
    Coates, P. T.
    TRANSPLANTATION, 2012, 94 (10) : 457 - 457
  • [5] Lipopolysaccharide-induced DC-SIGN/TLR4 crosstalk activates NLRP3 inflammasomes via MyD88-independent signaling in gastric epithelial cells
    Chen, Yufan
    Huang, Jiebin
    Xu, Chundi
    EXPERIMENTAL CELL RESEARCH, 2020, 396 (01)
  • [6] Activated Apoptotic Cells Induce Dendritic Cell Maturation via Engagement of Toll-like Receptor 4 (TLR4), Dendritic Cell-specific Intercellular Adhesion Molecule 3 (ICAM-3)grabbing Nonintegrin (DC-SIGN), and β2 Integrins
    Pathak, Sushil Kumar
    Skold, Annette E.
    Mohanram, Venkatramanan
    Persson, Catrine
    Johansson, Ulrika
    Spetz, Anna-Lena
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (17) : 13731 - 13742
  • [7] IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction - A comparative study of human clinical-applicable DC
    Boks, Martine A.
    Kager-Groenland, Judith R.
    Haasjes, Michiel S. P.
    Zwaginga, Jaap Jan
    van Ham, S. Marieke
    ten Brinke, Anja
    CLINICAL IMMUNOLOGY, 2012, 142 (03) : 332 - 342
  • [8] Triggering of TLR-3,-4, NOD2, and DC-SIGN reduces viral replication and increases T-cell activation capacity of HIV-infected human dendritic cells
    Cardinaud, Sylvain
    Urrutia, Alejandra
    Rouers, Angeline
    Coulon, Pierre-Gregoire
    Kervevan, Jerome
    Richetta, Clemence
    Bet, Anne
    Maze, Emmanuel A.
    Larsen, Martin
    Iglesias, Maria-Candela
    Appay, Victor
    Graff-Dubois, Stephanie
    Moris, Arnaud
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2017, 47 (05) : 818 - 829
  • [9] Human monocyte-derived dendritic cells stimulated with specific nondigestible oligosaccharides mimicking the functionality of breast milk oligosaccharides induce CD4+Foxp3high T cells
    Lehmann, S.
    Hiller, J.
    van Bergenhenegouwen, J.
    Knippels, L.
    Garssen, J.
    Traidl-Hoffmann, C.
    EXPERIMENTAL DERMATOLOGY, 2015, 24 (03) : E21 - E21
  • [10] Enterovirus-71 Virus-Like Particles Induce the Activation and Maturation of Human Monocyte-Derived Dendritic Cells through TLR4 Signaling
    Lin, Yu-Li
    Hu, Yu-Chen
    Liang, Cheng-Chao
    Lin, Shih-Yeh
    Liang, Yu-Chih
    Yuan, Hui-Ping
    Chiang, Bor-Luen
    PLOS ONE, 2014, 9 (10):