Intracellular protein degradation of BRD4 by dBET1 reveals conserved in vivo cereblon function in human and mouse T-cells

被引：0
|
作者：
Akuffo, Afua Adutwunnwa
Alontaga, Aileen
Metclaf, Rainer
Beatty, Matthew S.
McDaniel, Jessica
Gunawan, Steven
Ayaz, Muhammad
Becker, Andreas
Hesterberg, Rebecca S.
Goodheart, William E.
Yang, Yan
Daniel, Kenyon G.
Schonbrunn, Ernst
Guida, Wayne
Lawrence, Harshani
Lawrence, Nicholas
Epling-Burnette, Pearlie
机构：
来源：
JOURNAL OF IMMUNOLOGY | 2017年 / 198卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
52.18
引用
收藏
页数：4
相关论文
共 38 条
  • [1] Degradation of BRD4 Protein with dBET1 Inhibits Neurotoxic Effects of a-Synuclein Oligomers
    Zheng, Y. J.
    Zhang, P.
    Huang, P. T.
    Zhang, Y. H.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2024, 72 : S29 - S29
  • [2] Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood–brain barrier integrity
    Lei Liu
    Changjun Yang
    Bianca P. Lavayen
    Ryland J. Tishko
    Jonathan Larochelle
    Eduardo Candelario-Jalil
    Journal of Neuroinflammation, 19
  • [3] Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity
    Liu, Lei
    Yang, Changjun
    Lavayen, Bianca P.
    Tishko, Ryland J.
    Larochelle, Jonathan
    Candelario-Jalil, Eduardo
    JOURNAL OF NEUROINFLAMMATION, 2022, 19 (01)
  • [4] Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+T Cells
    Zhang, Weishi
    Prakash, Celine
    Sum, Calvin
    Gong, Yue
    Li, Yinghui
    Kwok, Jeffrey J. T.
    Thiessen, Nina
    Pettersson, Sven
    Jones, Steven J. M.
    Knapp, Stefan
    Yang, Henry
    Chin, Keh-Chuang
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (51) : 43137 - 43155
  • [5] THE SIMIAN IMMUNODEFICIENCY VIRUS NEF PROTEIN PROMOTES DEGRADATION OF CD4 IN HUMAN T-CELLS
    SANFRIDSON, A
    CULLEN, BR
    DOYLE, C
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (06) : 3917 - 3920
  • [6] Human T-Lymphotropic Virus Type 1 Tax Protein Complexes with P-TEFb and Competes for Brd4 and 7SK snRNP/HEXIM1 Binding
    Cho, Won-Kyung
    Jang, Moon Kyoo
    Huang, Keven
    Pise-Masison, Cynthia A.
    Brady, John N.
    JOURNAL OF VIROLOGY, 2010, 84 (24) : 12801 - 12809
  • [7] 4-1BB engineered human T-cells demonstrate enhanced function and mediate regression of established melanoma tumors
    Cohen, C. J.
    Horovitz-Fried, M.
    Morgan, R. A.
    Goldstein, R.
    Daniel-Meshulam, I.
    IMMUNOLOGY, 2012, 137 : 678 - 678
  • [8] PRIMING OF CD4+ T-CELLS SPECIFIC FOR CONSERVED REGIONS OF HUMAN-IMMUNODEFICIENCY-VIRUS GLYCOPROTEIN GP120 IN HUMANS IMMUNIZED WITH A RECOMBINANT ENVELOPE PROTEIN
    ABRIGNANI, S
    MONTAGNA, D
    JEANNET, M
    WINTSCH, J
    HAIGWOOD, NL
    SHUSTER, JR
    STEIMER, KS
    CRUCHAUD, A
    STAEHELIN, T
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) : 6136 - 6140
  • [9] In vivo anergized CD4+ T cells have defective expression and function of the activating protein-1 transcription factor
    Sundstedt, A
    Dohlsten, M
    JOURNAL OF IMMUNOLOGY, 1998, 161 (11): : 5930 - 5936
  • [10] NEF FROM PRIMARY ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SUPPRESSES SURFACE CD4 EXPRESSION IN HUMAN AND MOUSE T-CELLS
    ANDERSON, S
    SHUGARS, DC
    SWANSTROM, R
    GARCIA, JV
    JOURNAL OF VIROLOGY, 1993, 67 (08) : 4923 - 4931
1234