The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials

被引：18

作者：

Yarborough, Mark ^{[1
]}

Bredenoord, Annelien ^{[2
]}

D'Abramo, Flavio ^{[3
,4
]}

Joyce, Nanette C. ^{[1
,5
]}

Kimmelman, Jonathan ^{[6
]}

Ogbogu, Ubaka ^{[7
]}

Sena, Emily ^{[8
]}

Strech, Daniel ^{[9
,10
,11
]}

Dirnagl, Ulrich ^{[10
,11
]}

机构：

[1] Univ Calif Davis, Bioeth Program, Sacramento, CA 95817 USA

[2] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[3] Free Univ Berlin, Dahlem Res Sch, Berlin, Germany

[4] Max Planck Inst Hist Sci, Berlin, Germany

[5] Univ Calif Davis, Dept Phys Med & Rehabil, Sacramento, CA 95817 USA

[6] McGill Univ, Biomed Eth Unit, Studies Translat Eth & Med STREAM, Montreal, PQ, Canada

[7] Univ Alberta, Fac Law, Edmonton, AB, Canada

[8] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[9] Hannover Med Sch, Inst Eth Hist & Philosophy Med, Hannover, Germany

[10] Charite Univ Med Berlin, Berlin, Germany

[11] Berlin Inst Hlth, QUEST Ctr Transforming Biomed Res, Berlin, Germany

来源：

PLOS BIOLOGY | 2018年 / 16卷 / 06期

关键词：

THERAPEUTIC MISCONCEPTION; HYPE; RECOMMENDATIONS; 1ST-IN-HUMAN; STANDARDS; EFFICACY; SCIENCE;

D O I：

10.1371/journal.pbio.2006343

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Millions of people worldwide currently suffer from serious neurological diseases and injuries for which there are few, and often no, effective treatments. The paucity of effective interventions is, no doubt, due in large part to the complexity of the disorders, as well as our currently limited understanding of their pathophysiology. The bleak picture for patients, however, is also attributable to avoidable impediments stemming from quality concerns in preclinical research that often escape detection by research regulation efforts. In our essay, we connect the dots between these concerns about the quality of preclinical research and their potential ethical impact on the patients who volunteer for early trials of interventions informed by it. We do so in hopes that a greater appreciation among preclinical researchers of these serious ethical consequences can lead to a greater commitment within the research community to adopt widely available tools and measures that can help to improve the quality of research.

引用

页数：9