Human 5′→3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites

被引：316
|
作者：
West, S [1 ]
Gromak, N [1 ]
Proudfoot, NJ [1 ]
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源：
NATURE | 2004年 / 432卷 / 7016期
关键词：
D O I：
10.1038/nature03035
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Eukaryotic protein-encoding genes possess poly(A) signals that define the end of the messenger RNA and mediate downstream transcriptional termination by RNA polymerase II (Pol II)(1). Termination could occur through an 'anti-termination' mechanism whereby elongation factors dissociate when the poly(A) signal is encountered, producing termination-competent Pol II2,3. An alternative 'torpedo' model postulated that poly(A) site cleavage provides an unprotected RNA 5' end that is degraded by 5' --> 3' exonuclease activities ( torpedoes) and so
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收藏
页码：522 / 525
页数：4
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