Ruthenium(II)-catalyzed α-fluoroalkenylation of arenes via C-H bond activation and C-F bond cleavage

被引：31
|
作者：
Li, Na [1 ,2 ]
Chang, Junbiao [1 ]
Kong, Lingheng [3 ]
Li, Xingwei [1 ,3 ]
机构：
[1] Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Organ Funct Mol & Drug Innovat, Xinxiang 453007, Peoples R China
[2] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Peoples R China
[3] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 12期
关键词：
METAL-COMPLEXES; GEM-DIFLUOROALKENES; ARYL FLUORIDES; ANTICANCER AGENTS; FUNCTIONALIZATION; FLUORINATION; CATALYSIS; ACCESS; MONOFLUOROALKENYLATION; TRIFLUOROMETHYLATION;
D O I：
10.1039/c8qo00297e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ru(II)-Catalyzed efficient alpha-fluoroalkenylation of arenes has been realized with gem-difluorostyrene as an olefinating reagent. This coupling system is efficient with a broad substrate scope, providing 1,2-diaryl-substituted monofluoroalkenes with good to excellent regio- and stereoselectivities under silver-free conditions.
引用
收藏
页码：1978 / 1982
页数：5
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