Regioselective Gold-Catalyzed Oxidative C-N Bond Formation

被引：64

作者：

Marchetti, Louis ^{[1
]}

Kantak, Abhishek ^{[1
]}

Davis, Riley ^{[1
]}

DeBoef, Brenton ^{[1
]}

机构：

[1] Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

AMINATION;

D O I：

10.1021/ol5034805

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.

引用

页码：358 / 361

页数：4

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