Fatigue and depression predict health-related quality of life in patients with pediatric-onset multiple sclerosis

被引：30

作者：

Gravesande, Karin Storm Van's ^{[1
]}

Blaschek, Astrid ^{[2
]}

Calabrese, Pasquale ^{[3
]}

Rostasy, Kevin ^{[4
]}

Huppke, Peter ^{[5
]}

Kessler, Josef J. ^{[6
]}

Kalbe, Elke ^{[7
,8
]}

Mall, Volker ^{[1
]}

Kraus, V ^{[9
]}

Dornfeld, E. ^{[9
]}

Elpers, C. ^{[10
]}

Lohmann, H. ^{[10
]}

Weddige, A. ^{[11
]}

Hagspiel, S. ^{[12
]}

Kirschner, J. ^{[13
]}

Brehm, M. ^{[13
]}

Blank, C. ^{[14
]}

Schubert, J. ^{[14
]}

Schimmel, M. ^{[15
]}

Pachee, S. ^{[15
]}

Mohrbach, M. ^{[15
]}

Karenfort, M. ^{[16
]}

Kamp, G. ^{[16
]}

Luecke, T. ^{[17
]}

Neumann, H. ^{[17
]}

Lutz, S. ^{[18
]}

Gierse, A. ^{[18
]}

Sievers, S. ^{[18
]}

Schiffinann, H. ^{[19
]}

de Soye, I ^{[19
]}

Trollmann, R. ^{[20
]}

Candova, A. ^{[20
]}

Rosner, M. ^{[20
]}

Neu, A. ^{[21
]}

Romer, G. ^{[21
]}

Seidel, U. ^{[22
]}

John, R. ^{[22
]}

Hofmann, C. ^{[23
]}

Schulz ^{[23
]}

Kinder, S. ^{[24
]}

Bertolatus, A. ^{[24
]}

Scheidtmann, K. ^{[25
]}

Lasogga, R. ^{[25
]}

Leiz, S. ^{[26
]}

Alber, M. ^{[27
]}

Kranz, J. ^{[27
]}

Bajer-Kornek, B. ^{[28
]}

Seidl, R. ^{[28
]}

Novak, A. ^{[28
]}

机构：

[1] Tech Univ Munich, Dept Pediat Child & Adolescent Psychosomat, Heigelhofstr 63, D-81377 Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Dept Pediat Neurol & Dev Med, Dr von Hauner Childrens Hosp, Lindwurmstr 4, D-80337 Munich, Germany

[3] Univ Basel, Dept Psychol, Div Mol & Cognit Neurosci, Neuropsychol & Behav Neurol Unit, Birmannsgasse 8, CH-4055 Basel, Switzerland

[4] Witten Herdecke Univ, Childrens Hosp Datteln, Pediat Neurol, Dr Friedrich Steiner Str 5, D-5711 Datteln, Germany

[5] Univ Med Ctr Gottingen, Dept Pediat & Adolescent Med, Div Pediat Neurol, Robert Koch Str 40, D-37075 Gottingen, Germany

[6] Univ Hosp Cologne, Dept Neurol, Kerpenerstr 62, D-50937 Cologne, Germany

[7] Univ Hosp Cologne, Dept Med Psychol Neuropsychol & Gender Studies, Kerpenerstr 62, D-50937 Cologne, Germany

[8] Univ Hosp Cologne, Ctr Neuropsychol Diagnost & Intervent CeNDI, Kerpenerstr 62, D-50937 Cologne, Germany

[9] Tech Univ Munich, Dept Pediat Child & Adolescent Psychosomat, Munich, Germany

[10] Univ Hosp Munster, Dept Neuropediat, Munster, Germany

[11] Univ Hosp Gottingen, Dept Neuropediat, Gottingen, Germany

[12] Univ Hosp Innsbruck, Dept Neuropediat, Innsbruck, Austria

[13] Univ Hosp Freiburg, Dept Neuropediat, Freiburg, Germany

[14] Univ Hosp Landshut, Dept Neuropediat, Landshut, Germany

[15] Univ Hosp Augsburg, Dept Neuropediat, Augsburg, Germany

[16] Univ Hosp Dusseldorf, Dept Neuropediat, Dusseldorf, Germany

[17] Univ Hosp Bochum, Dept Neuropediat, Bochum, Germany

[18] Univ Hosp Essen, Dept Neuropediat, Essen, Germany

[19] Univ Hosp Nurnberg, Dept Neuropediat, Nurnberg, Germany

[20] Univ Hosp Erlangen, Dept Neuropediat, Erlangen, Germany

[21] Univ Hosp Hamburg, Dept Neuropediat, Hamburg, Germany

[22] Charite, Dept Neuropediat, Berlin, Germany

[23] Univ Hosp Mainz, Dept Neuropediat, Mainz, Germany

[24] Univ Hosp Dresden, Dept Neuropediat, Dresden, Germany

[25] Hegau Jugendwerk Gailingen, Gailingen, Germany

[26] Dritter Orden, Dept Pediat, Munich, Germany

[27] Univ Hosp Tubingen, Dept Neuropediat, Tubingen, Germany

[28] Univ Hosp Vienna, Dept Neurol & Neuropediat, Vienna, Austria

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 36卷

关键词：

Multiple sclerosis; Fatigue; Depression; Health-related quality of life; Pediatric; PSYCHOSOCIAL FEATURES; CHILDHOOD; CHILDREN; ADOLESCENTS; RELIABILITY; PEDSQL(TM); VERSION;

D O I：

10.1016/j.msard.2019.08.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Fatigue, depression and loss in health-related quality of life (HRQoL) have been reported to occur in a substantial amount of patients with pediatric-onset MS (POMS). This study aims to evaluate depression, fatigue and HRQoL and its relationship in a cohort of patients with POMS and matched healthy controls (HCs). Methods: In a multicenter cross-sectional study, Beck Depression Inventory II, Depressionstest fur Kinder, the Pediatric Quality of Life Inventory (PedsQL (TM)) 4.0 Generic Core Scale and the PedsQL (TM) Multidimensional Fatigue Scale were performed. Results: In a cohort of 106 patients with POMS and 210 matched HCs, patients were significantly more often depressed (21.7% vs. 11.4%, p = 0.014) experienced greater fatigue (40.6% vs. 17.3%, p < 0.001) and a greater loss of HRQoL (43.4% vs. 15%, p < 0.001) than controls. Depression predicted 51.8% of variance of fatigue. Fatigue was also predicted by female gender. Loss of HRQoL was predicted by EDSS, depression and fatigue. Depression and fatigue together explained 67.7% of variance of HRQoL. Conclusion: Patients with POMS are at a significant increased risk for depression, fatigue and loss of HRQoL. Furthermore, fatigue and depression significantly predict reduced HRQoL in POMS, suggesting that testing for these symptoms and early therapy is of utmost importance in all patients with POMS.

引用

页数：6

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