Visible Light/Tertiary Amine Promoted Synergistic Hydroxydifluoroacetamidation of Unactivated Alkenes under Air

被引：26
|
作者：
Sun, Bin [1 ]
Zhu, Rui [2 ]
Zhuang, Xiaohui [1 ]
Shi, Xiayue [2 ]
Huang, Panyi [2 ]
Yan, Zhiyang [1 ]
Yu, Chuanming [2 ]
Jin, Can [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 02期
基金：
中国国家自然科学基金;
关键词：
RADICAL-ADDITION; LIGHT PHOTOREDOX; DIFLUOROALKYLATION; FLUORINE; DIFLUOROMETHYLATION; CATALYSIS; OLEFINS;
D O I：
10.1021/acs.orglett.0c04216
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and novel method for regioselective hydroxydifluoroacetamidation of alkenes with bromodifluor-oacetamides has been achieved via a tandem radical pathway mediated by photoredox catalysis under metal-free conditions. This transformation proceeded smoothly in the presence of Rhodamine 6G, affording a series of alpha,alpha-difluoro-gamma-hydroxyacetamides in moderate to excellent yields. The significant advantages of this protocol are the low-cost photocatalyst, readily available starting materials, synthetic convenience, and wide functional group compatibility.
引用
收藏
页码：617 / 622
页数：6
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