The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease

被引：18

作者：

Lee, Hye Won ^{[1
]}

Chung, Sook Hee ^{[2
]}

Moon, Chang Mo ^{[3
]}

Che, Xiumei ^{[4
]}

Kim, Seung Won ^{[1
]}

Park, Soo Jung ^{[1
]}

Hong, Sung Pil ^{[1
]}

Kim, Tae Il ^{[1
]}

Kim, Won Ho ^{[1
]}

Cheon, Jae Hee ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Inst Gastroenterol, Seoul, South Korea

[2] Ajou Univ, Coll Med, Dept Internal Med, Suwon 441749, South Korea

[3] Ewha Womans Univ, Dept Internal Med, Sch Med, 1071 Anyangcheon Ro, Seoul, South Korea

[4] Yonsei Univ, Brain Korea Plus Project Med Sci 21, Seoul 120749, South Korea

来源：

MEDICINE | 2016年 / 95卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

INTESTINAL BEHCETS-DISEASE; CROHNS-DISEASE; ULCERATIVE-COLITIS; ENDOSCOPIC ACTIVITY; ADAPTIVE IMMUNITY; RANDOMIZED-TRIAL; SES-CD; INTERLEUKIN-12; VALIDATION; CYTOKINE;

D O I：

10.1097/MD.0000000000003772

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic variants in IL12B, encoding the p40 subunit common in interleukin-12 (IL-12) and interleukin-23, were identified as the susceptibility loci for inflammatory bowel disease (IBD). This study aimed to identify the correlation of serum IL-12B expression with disease activity in patients with IBD and evaluate the possibility of IL12B as a biomarker for assessing inflammatory status in IBD. A total of 102 patients with IBD, including 38, 32, and 32 patients with Crohn's disease (CD), ulcerative colitis (UC), and intestinal Behc, et's disease (intestinal BD), respectively, were included. The clinical and laboratory data from the patients were collected at the time of serum IL-12B measurement. Serum IL-12B levels were measured using an enzyme-linked immunosorbent assay. The median IL-12B levels in patients with CD, UC, and intestinal BD were significantly higher than those in controls (1.87, 2.74, and 2.73 pg/mL, respectively, vs. 1.42 pg/mL, all P < 0.05). IL-12B concentrations were associated with disease activity in patients with UC and intestinal BD but not in those with CD. IL-12B levels were increased with increasing disease activity in patients with UC (P < 0.001). Likewise, patients with active intestinal BD had higher IL-12B levels than those without active disease (P = 0.008). IL-12B levels were correlated with the endoscopic disease activity of UC (P = 0.002) and intestinal BD (P = 0.001) but not that of CD. Serum IL-12B levels were significantly correlated with clinical and endoscopic disease activity in patients with UC and intestinal BD, suggesting its potential use as a biomarker for assessing disease activity in these patients.

引用

页数：8