Invasive amoebiasis, the infection of humans by Entamoeba histolytica associated with dysentery and liver abscess, is still a major cause of morbidity and mortality in developing countries. This review attempts to reduce the gap between the overwhelming amount of information coming recently from laboratory research and the sparse contributions resulting from clinical and epidemiological investigations of the second parasitic cause of death resulting from a protozoan parasite. Curr Opin Infect Dis 13:451-456. (C) 2000 Lippincott Williams & Wilkins.