The structural and surface properties of Al-doped hydroxyapatite (Ca5(PO4)3OH) nanorods and their applications for pH-induced drug delivery

被引：11

作者：

Fan, Qingyu ^{[1
]}

Fan, Fan ^{[2
]}

Xu, Wei ^{[3
]}

Zhang, Hao ^{[4
]}

Liu, Na ^{[5
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 2, Xian 710004, Peoples R China

[2] Xian Univ Posts & Telecommun, Sch Automat, Xian 710121, Peoples R China

[3] Wuyi Univ, Sch Appl Phys & Mat, Jiangmen 529020, Guangdong, Peoples R China

[4] Xi An Jiao Tong Univ, Dept Pathol, Affiliated Hosp 2, Xian 710004, Peoples R China

[5] Xi An Jiao Tong Univ, Dept Ultrasound, Affiliated Hosp 2, Xian 710004, Peoples R China

来源：

JOURNAL OF ALLOYS AND COMPOUNDS | 2021年 / 879卷

关键词：

Hydroxyapatite; Al doping; Drug delivery; Cancer treatment; Doxorubicin; Hyaluronic acid; ISOCARBOPHOS DEGRADING BACTERIUM; MESOPOROUS SILICA NANOPARTICLES; DOXORUBICIN; GRAPHENE; RELEASE; DEGRADATION; METHYL; SYSTEM;

D O I：

10.1016/j.jallcom.2021.160414

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this paper, we reported Al-doped hydroxyapatite (Al-HAp) nanorods with surface functionalization of hyaluronic acid (HA) for pH-responsive delivery of doxorubicin (DOX) for cancer treatment. The specific surface area and the crystal structure of both HAp and Al-HAp are studied. It is learned that the HAp and Al-HAp have similar crystal structures, but Al-HAp shows 10% larger specific surface area than HAp, which results in 30% higher DOX loading capacity than HAp nanorods, due to the increased surface area and enlarged pore size by Al doping. Moreover, the DOX loaded Al-HAp/HA was highly pH-responsive and exhibited outstanding biocompatibility and significantly enhanced anti-cancer killing effects. (c) 2021 Elsevier B.V. All rights reserved.

引用

页数：8

共 42 条

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